BOUASLA I, BOUASLA A, BOUMENDJEL A, EL-FAKI A and MESSARAH M (2014) Antioxidant effect of alpha lipoic acid on hepatotoxicity induced by aluminium chloride in rats. International Journal of Pharmaceutical Sciences Review and Research , 29(2), 19-25, Scopus
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Abstract
The present study was planned to investigate the ameliorative effects of α-lipoic acid (α-LA) supplementation against aluminium
chloride (AlCl
3
) induced hepatotoxicity in rats. The results showed that rats consuming diets with AlCl
added had poor growth
performance, and most serum hematological indexes were significantly altered compared to the control. Biochemical results
showed that lipid peroxidation increased significantly in Al-treated rats, as evidenced by high liver malondialdehyde (MDA) levels.
Alteration of the antioxidant system in treated group was confirmed by the significant decline of superoxide dismutase (SOD),
catalase (CAT), glutathione peroxidase (GPx) activities and reduced glutathione (GSH) content in liver. Moreover, AlCl
International Journal of Pharmaceutical Sciences Review and Research
Available online at www.globalresearchonline.net
3
exposure
induced an increase in the activities of the aspartate transaminase (AST), alanine transaminase (ALT), lactate deshydrogenase (LDH)
and bilirubin levels, while albumin and total protein were significantly decreased. These results strongly suggest that aluminium
affected antioxidant defence system and both haematological and biochemical parameters, co-administration of α-lipoic acid
exerted a protective effect against aluminium induced oxidative stress.
chloride (AlCl
3
) induced hepatotoxicity in rats. The results showed that rats consuming diets with AlCl
added had poor growth
performance, and most serum hematological indexes were significantly altered compared to the control. Biochemical results
showed that lipid peroxidation increased significantly in Al-treated rats, as evidenced by high liver malondialdehyde (MDA) levels.
Alteration of the antioxidant system in treated group was confirmed by the significant decline of superoxide dismutase (SOD),
catalase (CAT), glutathione peroxidase (GPx) activities and reduced glutathione (GSH) content in liver. Moreover, AlCl
International Journal of Pharmaceutical Sciences Review and Research
Available online at www.globalresearchonline.net
3
exposure
induced an increase in the activities of the aspartate transaminase (AST), alanine transaminase (ALT), lactate deshydrogenase (LDH)
and bilirubin levels, while albumin and total protein were significantly decreased. These results strongly suggest that aluminium
affected antioxidant defence system and both haematological and biochemical parameters, co-administration of α-lipoic acid
exerted a protective effect against aluminium induced oxidative stress.
Information
| Item Type | Journal |
|---|---|
| Divisions | |
| ePrint ID | 4880 |
| Date Deposited | 2024-02-23 |
| Further Information | Google Scholar |
| URI | https://univ-soukahras.dz/en/publication/article/4880 |
BibTex
@article{uniusa4880,
title={Antioxidant effect of alpha lipoic acid on hepatotoxicity induced by aluminium chloride in rats},
author={BOUASLA I, BOUASLA A, BOUMENDJEL A, EL-FAKI A and MESSARAH M},
journal={International Journal of Pharmaceutical Sciences Review and Research}
year={2014},
volume={29},
number={2},
pages={19-25},
publisher={Scopus}
}
title={Antioxidant effect of alpha lipoic acid on hepatotoxicity induced by aluminium chloride in rats},
author={BOUASLA I, BOUASLA A, BOUMENDJEL A, EL-FAKI A and MESSARAH M},
journal={International Journal of Pharmaceutical Sciences Review and Research}
year={2014},
volume={29},
number={2},
pages={19-25},
publisher={Scopus}
}