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This study compares hepatic steatosis (fatty liver disease) in humans and bovines, focusing on the macroscopic, histological, biochemical, and statistical differences between the two species. Hepatic steatosis is a condition characterized by the abnormal accumulation of lipids in the liver and has varied etiologies, pathophysiological mechanisms, and clinical outcomes across species. In humans, hepatic steatosis is often associated with metabolic disorders such as obesity, diabetes, and insulin resistance, leading to complications such as non-alcoholic steatohepatitis (NASH) and liver fibrosis. Histologically, human livers showed significant macrovacuolar steatosis, marked lobular inflammation, and fibrosis, with a higher oxidative stress marker (MDA) and liver enzyme levels (ALT, AST, GGT). In contrast, bovines, particularly dairy cows during lactation, exhibit a more transient and compensatory form of hepatic steatosis. The liver in bovines displayed moderate macrovesicular steatosis without significant inflammation or fibrosis, and triglyceride levels were higher than in humans, yet there were no signs of severe liver damage. Statistical analysis revealed significant differences in triglyceride levels, oxidative stress, and liver enzyme activity between the two species. This study highlights the adaptive metabolic mechanisms in bovines that allow them to tolerate higher lipid levels without progressing to severe liver damage, providing insights that could inform therapeutic strategies for human hepatic steatosis. Understanding these species-specific differences is crucial for developing targeted interventions in both human and veterinary medicine.

Item Type	Journal
Divisions	» Algerian International Veterinary Journal
ePrint ID	5282
Date Deposited	2025-01-16
Further Information	Google Scholar
URI	https://univ-soukahras.dz/en/publication/article/5282

@article{uniusa5282,
    title={Comparison of Hepatic Steatosis Mechanisms in Humans and Bovines in El-Oued Region of Algeria.},
    author={Rahmoun Djallal Eddine, Bentazir Allaoua Chaouki, Lieshchova Marina and Mylostyvyi Roman},
    journal={Algerian International Veterinary Journal}
    year={2024},
    volume={0},
    number={1},
    pages={09-15},
    publisher={}
}