Abstract

The functioning of the pineal gland, the transducer body of environmental information to the neuroendocrine
system was subjected to a circadian rhythm.
Melatonin is the main neuro-hormone expressing this operation. It is synthesized in the pinealocytes after
conversion of serotonin via N-acetyl-transferase enzyme, the same subject to a photoperiodic modulation (activation of
dark inhibition by light). Some scientists have suggested that melatonin is involved in diabetic disease and which expresses
have a diabetogenic effect. To this study the effect of this hormone on glucose metabolism has long been subject to
controversy agreeing in effect and hyperinsulinemic hypoglycaemic effect. In order to illustrate the level of interaction of
melatonin with neuro-immune- corticotrophin axis and its impact on carbohydrate metabolism, we studied the impact
homeostatic (glucose) through the solicitation of two control systems (gland pineal and corticotrophin axis). We and found
that melatonin could have an indirect influence on insulin control (glucose metabolism) to the levels of the growth
hormone axis (somatostatin) and adrenocorticotropic (corticotrophin). In addition, we have suggested that melatonin might
limit the hyperglycaemic action of corticosteroids by direct action at peripheral level.
KEYWORDS: Pineal Gland, Melatonin, Neuro-Immuno-Corticotrop

Information

Item Type:	Journal
Divisions:	» Laboratory for Terrestrial and Aquatic Ecosystems
ePrint ID:	683
Date Deposited:	2017-03-03
Further Information:	Google Scholar
URI:	https://www.univ-soukahras.dz/en/publication/article/683

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