Résumé

Warionia saharae Benth. & Coss. (Asteraceae) is an endemic species of North Africa naturally
grown in the southwest of the Algerian Sahara. In the present study, this species’ hydromethanolic
leaf extract was investigated for its phenolic profile characterized by ultra-high-performance liquid chromatography coupled with a diode array detector and an electrospray mass spectrometer
(UHPLC-DAD-ESI/MS). Additionally, the chemical composition of W. saharae was analyzed by gas
chromatography–mass spectrometry, and its antioxidant potential was assessed through five in vitro
tests: DPPH scavenging activity, ABTS+ scavenging assay, galvinoxyl scavenging activity, ferric
reducing power (FRP), and cupric reducing antioxidant capacity. The UHPLC-DAD-ESI/MS analysis
allowed the detection and quantification of 22 compounds, with taxifolin as the dominant compound.
The GC–MS analysis allowed the identification of 37 compounds, and the antioxidant activity data
indicate that W. saharae extract has a very high capacity to capture radicals due to its richness in compounds with antioxidant capacity. The extract also showed potent -glucosidase inhibition as
well as a good anti-inflammatory activity. However, weak anti--amylase and anticholinesterase
activities were recorded. Moreover, an in silico docking study was performed to highlight possible
interactions between three significant compounds identified in W. saharae extract and -glucosidase
enzyme.

Information

Item Type:	Journal
Divisions:
ePrint ID:	2795
Date Deposited:	2021-10-10
Further Information:	Google Scholar
URI:	https://www.univ-soukahras.dz/fr/publication/article/2795

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