Department of Biological Sciences

https://www.univ-soukahras.dz/en/dept/bio

Lecturer	Choukri BAROUR
Information	Bachelor - biochemistry Department of Biological Sciences Website : https://www.univ-soukahras.dz/en/module/2749 Semester : S5 Unit : UEF3.1.2 Credit : 6 Coefficient: 3
Content	Contents : 1. General information on immune responses: Bone marrow; Thymus; Lymph nodes; Mucosa-associated lymphoid tissues (MALT); Spleen; Antigen-presenting cells (APCs and others). 2. Haematopoiesis: Control/regulation of the differentiation and proliferation of haematopoietic stem cells; Lymphopoiesis; Myelopoiesis. 3. Activation of lymphocytes (T and B). 4. Antibody synthesis and diversity; B epitopes; differentiation and maturation of B lymphocytes. 5. Cellular immunity: T helper lymphocytes and lymphokine production; Cytotoxic T lymphocytes; T lymphocyte receptors; Phenomenon of cytotoxicity. 6. T-B interaction; Functional consequences following antigen recognition: (Transduction signals and transcription); T signalling, Early and late activation events, the ca2+/Calcineurin connection, involvement of G proteins: The main regulatory molecules (CD 2, CD 28, CD45); B signalling/Early and late phosphorylation events following antigen binding to the BCR. Molecules regulating BCR activation: CD19, CD21, CD80 (B7), CD 40; feedback regulation. 7. Acquisition of memory; speciality of acquired immunity; vaccination. 8. Hybridomas and monoclonal antibodies. 9. Control of the immune response. 10. Development of the immune system. 11. Anti-infectious immunity. 12. Immunopathology and immunotherapy.
Evaluation	Assessment and weighting Assessment Weighting (%) Final examination 60 Tutorial 40 Total 100 Tutorial 100% : 40% -> a single presentation. 50% -> 2 micro-interrogations. 10% -> attendance.